In his final years he was unable to tie his own shoes

“Lou Gehrig hit 493 home runs and batted .340 in 2,130 consecutive games. But in his final years he was unable to tie his own shoes.
Help find a cure for Lou Gehrig’s Disease (ALS). To donate call 800-672-8857.”

In this ad from the ALS Association Greater New York Chapter actual shoe laces were laced through die-cut holes on back pages of magazines and left untied.

Advertiser:
ALS Association Greater New York Chapter
Agency:
BBDO, New York, USA
Additional credits:
Creative Directors: Frank Anselmo, Jayson Atienza
Art Directors / Copywriters: Jeseok Yi, Jayson Atienza, Frank Anselmo
Chief Creative Officers: David Lubars, Bill Bruce
Source:
I Believe In Advertising